Aldactone 100

Aldactone 100

$29.00

Manufacturer: RPG
Category: PCT
Substance: Aldactone
Package: 100mg 30 pills

Category: .

Product Description

Description of the pharmacological action

It is a competitive antagonist of aldosterone. The distal renal tubule increases the excretion of sodium and water, reduces – potassium. Lowers blood pressure.

Indications

Hyperaldosteronism (primary and idiopathic), hyperaldosteronism diagnostics, Adrenal adenoma producing aldosterone; edema syndrome in chronic heart failure, liver cirrhosis, nephrotic syndrome, nephropathy pregnant; hypertension, hypokalemia, as an aid in malignant hypertension, hypokalemia, hypokalemia prophylaxis in patients receiving cardiac glycosides.

release Form

film-coated tablets 25 mg; the blister 10, the box (box) 2
coated tablets 100 mg; the blister 10, the box (box) 2.

pharmacodynamics

Potassium-sparing diuretic action is due to antagonism of aldosterone (ISS adrenocortical hormone) contributing Na + reabsorption in the renal tubules and excretion of K +. Spironolactone – a competitive antagonist of aldosterone for influencing the distal nephron (competes for binding sites on the cytoplasmic protein receptors, reduces the synthesis permeases in aldosterone-sensitive portion of the collecting ducts and distal tubules), increases the excretion of Na +, Cl- and water, reduces the excretion of K + and urea It reduces titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is unstable. The diuretic effect is seen on the 2-5 day of treatment.

Contraindications

Hypersensitivity, anuria, renal failure (acute, chronic a significant reduction in renal function); hyperkalemia, pregnancy (I term).

Side effects

Dyspepsia, diarrhea, headache, drowsiness, gynecomastia, decreased erectile dysfunction, menstrual disorders, menstrualnopodobnye bleeding in menopause.

Dosing and Administration

Inside. Adults with primary hyperaldosteronism in preparation for surgery – 100-400 mg per day, in case of failure of operation selected minimum effective dose; edema (cardiac, hepatic and renal origin) in an initial dose – 100 mg per day in divided doses, after 5 days, depending on the clinical effect, the dose is reduced to 25 mg or increased to 200 mg; in hypertension – at an initial dose of 50-100 mg per day in divided doses, 2 weeks is possible to increase or decrease the dose (depending on effect); when hypokalemia caused by diuretics, – 25-100 mg per day. Children – 3.3 mg / kg of body weight per day.

while taking precautions

During treatment to avoid excessive intake of potassium. It is not recommended to combine with others. Potassium-sparing diuretics. With simultaneous administration with diuretics and antihypertensive agents necessary to reduce the dose.